Δ-11-Tetrahydrocannabinol

Δ-11-Tetrahydrocannabinol
Clinical data
Other namesDelta-11-THC, Exo-THC, Δ11-THC, Δ9(11)-THC, exo-Tetrahydrocannabinol
ATC code
  • None
Identifiers
  • (6aR,10aR)-6,6-dimethyl-9-methylidene-3-pentyl-7,8,10,10a-tetrahydro-6aH-benzo[c]chromen-1-ol
CAS Number
PubChem CID
Chemical and physical data
FormulaC21H30O2
Molar mass314.469 g·mol−1
3D model (JSmol)
  • CCCCCC1=CC(=C2[C@@H]3CC(=C)CC[C@H]3C(OC2=C1)(C)C)O
  • InChI=1S/C21H30O2/c1-5-6-7-8-15-12-18(22)20-16-11-14(2)9-10-17(16)21(3,4)23-19(20)13-15/h12-13,16-17,22H,2,5-11H2,1,3-4H3/t16-,17-/m1/s1
  • Key:AOYYFUGUUIRBML-IAGOWNOFSA-N

Δ-11-Tetrahydrocannabinol (Delta-11-THC, Exo-THC, Δ11-THC, Δ9(11)-THC, exo-Tetrahydrocannabinol) is a rare isomer of tetrahydrocannabinol (Δ9-THC), developed in the 1970s. It can be synthesised from Δ8-THC by several different routes, though only the (6aR, 10aR) enantiomer is known.

In recent studies in 2022 it was found to "significantly reduce" the effects of Δ9-THC and has been suggested to act as a CB1 receptor antagonist in humans, with the cited study showing "one partial success in the quest for an antagonist is the fact that D9,11-THC was found to significantly reduce the effect of D9-THC" and did not substitute for Δ9-THC in rhesus monkeys. It has been identified as a component of grey market vaping liquids sold for use in humans. Δ11-THC has been identified as an impurity found in pharmaceutical dronabinol.

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