14-3-3 protein
| 14-3-3 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
Cartoon diagram of Human 14-3-3 protein beta PDB entry 2bq0 | |||||||||
| Identifiers | |||||||||
| Symbol | 14-3-3 | ||||||||
| Pfam | PF00244 | ||||||||
| InterPro | IPR000308 | ||||||||
| SMART | 14_3_3 | ||||||||
| PROSITE | PDOC00633 | ||||||||
| SCOP2 | 1a4o / SCOPe / SUPFAM | ||||||||
| |||||||||
14-3-3 proteins are a family of conserved regulatory molecules that are expressed in all eukaryotic cells. 14-3-3 proteins have the ability to bind a multitude of functionally diverse signaling proteins, including kinases, phosphatases, and transmembrane receptors. More than 200 signaling proteins have been reported as 14-3-3 ligands.
Elevated amounts of 14-3-3 protein in cerebrospinal fluid are usually a sign of rapid neurodegeneration; a common indicator of Creutzfeldt–Jakob disease.