1910 U.S. National Championships – Men's singles

Men's singles
1910 U.S. National Championships
Champion William Larned
Runner-up Tom Bundy
Score6–1, 5–7, 6–0, 6–8, 6–1

Defending champion William Larned defeated Tom Bundy in the Challenge Round 6–1, 5–7, 6–0, 6–8, 6–1 to win the men's singles tennis title at the 1910 U.S. National Championships. Bundy defeated Beals Wright in the All Comers' Final.

The event was held at the Newport Casino in Newport, R.I. in the United States. There were more than 128 players in the draw.