1921 All-Pro Team

The 1921 All-Pro Team represented the All-Pro team for the 1921 season of the American Professional Football Association (APFA), later renamed the National Football League (NFL). It was compiled by the Buffalo Evening News.

Bruce Copeland, sports editor of the Rock Island Argus, who published an extensive All-Star team for the APFA in 1920, was replaced by J.L. Hughes by the time of the 1921 season and no comparable effort was made by that publication following the association's second year.