1921 Buffalo All-Americans season
| 1921 Buffalo All-Americans season | |
|---|---|
| Head coach | Tommy Hughitt |
| Home stadium | Canisius College |
| Results | |
| Record | 10–1–2 Overall 9–1–2 APFA |
| Division place | 2nd APFA |
| Playoffs | Lost 10–7 to Chicago Staleys |
The 1921 Buffalo All-Americans season was their second completed in the fledgling American Professional Football Association (APFA), later known as the National Football League (NFL). The team played 10 of their 12 league games at home, finishing 9–1–2 against league opponents.
The team lost the league title to the Chicago Staleys in a disputed tiebreaker, played on the road the day after a game played against another opponent in Buffalo.