1942 U.S. National Championships – Women's singles
| Women's singles | |
|---|---|
| 1942 U.S. National Championships | |
| Champion | Pauline Betz |
| Runner-up | Louise Brough |
| Score | 4–6, 6–1, 6–4 |
Second-seeded Pauline Betz defeated first-seeded Louise Brough 4–6, 6–1, 6–4 in the final to win the women's singles tennis title at the 1942 U.S. National Championships.