1965 U.S. National Championships – Men's singles
| Men's singles | |
|---|---|
| 1965 U.S. National Championships | |
| Champion | Manuel Santana |
| Runner-up | Cliff Drysdale |
| Score | 6–2, 7–9, 7–5, 6–1 |
| Draw | 128 |
| Seeds | 8 |
Manuel Santana defeated Cliff Drysdale 6–2, 7–9, 7–5, 6–1 in the final to win the men's singles tennis title at the 1965 U.S. National Championships.