1965 U.S. National Championships – Men's singles

Men's singles
1965 U.S. National Championships
Champion Manuel Santana
Runner-up Cliff Drysdale
Score6–2, 7–9, 7–5, 6–1
Draw128
Seeds8

Manuel Santana defeated Cliff Drysdale 6–2, 7–9, 7–5, 6–1 in the final to win the men's singles tennis title at the 1965 U.S. National Championships.