1965 U.S. National Championships – Women's singles

Women's singles
1965 U.S. National Championships
Champion Margaret Smith
Runner-up Billie Jean Moffitt
Score8–6, 7–5
Seeds8

First-seeded Margaret Smith defeated fifth-seeded Billie Jean Moffitt 8–6, 7–5 in the final to win the women's singles tennis title at the 1965 U.S. National Championships.