1978 US Open – Women's singles

Three-time defending champion Chris Evert defeated Pam Shriver in the final, 7–5, 6–4 to win the women's singles tennis title at the 1978 US Open. It was her fourth consecutive US Open title (an Open Era record), her fourth US Open singles title overall, and her eighth major singles title overall. For the third consecutive year, Evert did not lose a set during the tournament. At 16 years and two months of age, Shriver was the youngest major finalist in the Open Era and the youngest finalist at the US Open.

This was the first edition of the US Open to be played on hard courts, and the first to be held at the National Tennis Center in Flushing Meadows, relocating from its former site at Forest Hills.

This marked the final major appearance for two-time major champion and former singles world No. 2 Nancy Richey; she lost in the first round to Lesley Hunt.