1980–81 2. Bundesliga

2. Bundesliga
Season1980–81
ChampionsNord: Werder Bremen
Süd: SV Darmstadt 98
PromotedNord: Werder Bremen
Eintracht Braunschweig
Süd: SV Darmstadt 98
RelegatedNord: 12 clubs
Süd: 10 clubs
Matches playedNord: 462
Süd: 380
Top goalscorerNord: Frank Mill
(40 goals)
Süd: Horst Neumann
(26 goals)
Average attendanceNord: 5,672
Süd: 4,379

The 1980–81 2. Bundesliga season was the seventh season of the 2. Bundesliga, the second tier of the German football league system. It was played in two regional divisions, Nord and Süd. This was the final season of the original two region 2. Bundesliga, as the DFB sought to integrate the Nord and Süd divisions into a single division for the next campaign. This meant 22 teams faced the drop to the Oberliga (12 from the Nord, 10 from the Süd). There were three promotion spots to the Bundesliga on offer, while the remaining teams would enter the new single league 2. Bundesliga in the next season.

Werder Bremen, Eintracht Braunschweig and SV Darmstadt 98 were promoted to the Bundesliga while twenty two clubs were relegated to the Oberligas.