1980–81 Alpha Ethniki
| Season | 1980–81 |
|---|---|
| Champions | Olympiacos 22nd Greek title |
| Relegated | Panachaiki Atromitos |
| European Cup | Olympiacos |
| UEFA Cup | Aris Panathinaikos |
| Cup Winners' Cup | PAOK |
| Matches played | 306 |
| Goals scored | 709 (2.32 per match) |
| Top goalscorer | Dinos Kouis (21 goals) |
← 1979–80 1981–82 → | |
The 1980–81 Alpha Ethniki was the 45th season of the highest football league of Greece. The season began on 7 September 1980 and ended on 14 June 1981. Olympiacos won their second consecutive and 22nd Greek title.
The point system was: Win: 2 points - Draw: 1 point.