1980–81 Anglo-Scottish Cup
| Tournament details | |
|---|---|
| Country | England Scotland |
| Teams | 20 |
| Final positions | |
| Champions | Chesterfield |
| Runners-up | Notts County |
The 1980–81 Anglo-Scottish Cup was the sixth and last edition of the tournament. It was won by Chesterfield, who beat Notts County in a two-legged final by 2–1 on aggregate.