1980–81 Cypriot First Division
| Season | 1980–81 |
|---|---|
| Champions | Omonia (10th title) |
| Relegated | |
| European Cup | Omonia (1st round) |
| UEFA Cup | APOEL (1st round) |
| Cup Winners' Cup | Enosis (1st round; via Cypriot Cup) |
| Matches played | 182 |
| Goals scored | 450 (2.47 per match) |
| Top goalscorer | Sotiris Kaiafas (14 goals) |
← 1979–80 1981–82 → | |
The 1980–81 Cypriot First Division was the 42nd season of the Cypriot top-level football league. Omonia won their 10th title.