1980 US Open – Women's singles

Women's singles
1980 US Open
Champion Chris Evert
Runner-up Hana Mandlíková
Score5–7, 6–1, 6–1
Draw96
Seeds16

Chris Evert-Lloyd defeated Hana Mandlíková in the final, 5–7, 6–1, 6–1 to win the women's singles tennis title at the 1980 US Open. It was her fifth US Open title and eleventh major singles title overall.

Tracy Austin was the defending champion, but lost in the semifinals to Evert in a rematch of the previous year's final.