1980 US Open – Women's singles
| Women's singles | |
|---|---|
| 1980 US Open | |
| Champion | Chris Evert |
| Runner-up | Hana Mandlíková |
| Score | 5–7, 6–1, 6–1 |
| Draw | 96 |
| Seeds | 16 |
Chris Evert-Lloyd defeated Hana Mandlíková in the final, 5–7, 6–1, 6–1 to win the women's singles tennis title at the 1980 US Open. It was her fifth US Open title and eleventh major singles title overall.
Tracy Austin was the defending champion, but lost in the semifinals to Evert in a rematch of the previous year's final.