1981 French Open – Women's singles

Women's singles
1981 French Open
Champion Hana Mandlíková
Runner-up Sylvia Hanika
Score6–2, 6–4
Seeds16

Hana Mandlíková defeated Sylvia Hanika in the final, 6–2, 6–4 to win the women's singles tennis title at the 1981 French Open. It was her second major singles title.

Chris Evert was the two-time defending champion, but lost in the semifinals to Mandlíková. It was her first defeat at the French Open since 1973, and the first time in six tournament appearances that she failed to reach the final.