1991 US Open – Women's singles

Women's singles
1991 US Open
Champion Monica Seles
Runner-up Martina Navratilova
Score7–6(7–1), 6–1
Draw128
Seeds16

Monica Seles defeated Martina Navratilova in the final, 7–6(7–1), 6–1 to win the women's singles tennis title at the 1991 US Open. It was her first US Open title and fourth major title overall. With the win, Seles recaptured the world No. 1 ranking from Steffi Graf, and would hold it until her 1993 stabbing.

Gabriela Sabatini was the defending champion, but lost in the quarterfinals to Jennifer Capriati.

This marked the first major in which future champion, three-time major champion and world No. 1 Lindsay Davenport competed in the main draw; she lost in the first round to Debbie Graham.