1999–2000 ANAPROF
| Season | 1999–2000 |
|---|---|
| Champions | Tauro |
| Relegated | Atlético Municipal Colón |
| Copa Interclubes UNCAF | Tauro Plaza Amador |
| Matches played | 110 |
| Goals scored | 302 (2.75 per match) |
| Top goalscorer | René Mendieta (15) |
| Biggest home win | Sporting '89 6–0 Eurokickers |
| Biggest away win | Chiriquí 1–5 Panamá Viejo Tauro 2–6 Árabe Unido |
| Highest scoring | Tauro 2–6 Árabe Unido |
← 1988 2000–01 → | |
The ANAPROF 1999–2000 season was the twelfth season since its establishment. It began on August 1, 1999, and ended on January 30, 2000. 10 teams competed in the league, 9 of which returned from the previous season and 1 of which was promoted from Primera A.
Tauro were crowned champions after defeating Plaza Amador 2-0 in the Rommel Fernández becoming Tauro's fifth title in its history. After clinching this title Tauro earned the Panama 1 spot in the 2001 season of the Copa Interclubes UNCAF while Plaza Amador earned the Panama 2 spot as the runner-up.
Previous to the start of the season there was a championship that went on from April to July amongst the participating teams to determine who would play in the 2000 season of the Copa Interclubes UNCAF; the 1999–2000 Campeonato Apertura. Panamá Viejo was crowned champion on July 2 after defeating Tauro 2-0.