20α-Dihydrotrengestone

20α-Dihydrotrengestone
Clinical data
Other names	20α-DHTG; 20α-Hydroxytrengestone; 6-Chloro-20(S)-hydroxy-9β,10α-pregna-1,4,6-trien-3-one
Drug class	Progestin; Progestogen
Pharmacokinetic data
Elimination half-life	8–14 hours
Identifiers
CAS Number	26136-53-8 ;
Chemical and physical data
Formula	C21H26ClO2
Molar mass	345.89 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O([H])[C@@](C)[C@]([H])1CC[C@]([H])2[C@@]([H])3C=C(Cl)C4=CC(C=C[C@@]4(C)[C@]3([H])CC[C@@]21C)=O;
	InChI InChI=1S/C21H26ClO2/c1-12(23)15-4-5-16-14-11-19(22)18-10-13(24)6-8-21(18,3)17(14)7-9-20(15,16)2/h6,8,10-11,14-17,23H,4-5,7,9H2,1-3H3/t14-,15+,16-,17+,20+,21-/m0/s1; Key:YOKUOTGYGGEOMR-OAYGGAORSA-N;

20α-Dihydrotrengestone (20α-DHTG), also known as 20α-hydroxytrengestone, as well as 6-chloro-20(S)-hydroxy-9β,10α-pregna-1,4,6-trien-3-one, is a progestin and the major active metabolite of trengestone. It appears that trengestone is a prodrug of 20α-DHTG, as it is largely transformed into this metabolite when given orally in humans. 20α-DHTG has potent progestogenic activity similarly to trengestone.