2000 US Open – Men's singles
| Men's singles | |
|---|---|
| 2000 US Open | |
| Champion | Marat Safin |
| Runner-up | Pete Sampras |
| Score | 6–4, 6–3, 6–3 |
| Draw | 128 |
| Seeds | 16 |
Marat Safin defeated Pete Sampras in the final, 6–4, 6–3, 6–3 to win the men's singles tennis title at the 2000 US Open. It was his first major title.
Andre Agassi was the defending champion, but lost in the second round to Arnaud Clément.
The tournament marked the first major main draw appearance of future world No. 1 and future champion Andy Roddick, and the first US Open main draw appearance of future world No. 1, five-time US Open champion, and 20-time major champion Roger Federer.