2001 Indianapolis Colts season

The 2001 Indianapolis Colts season was the 49th season for the team in the National Football League (NFL) and 18th in Indianapolis. The Colts failed to improve on their 10–6 record from 2000 and finished the season with a record of 6–10, finished fourth in the AFC East division, and missed the playoffs for the first time since 1998. In the process the Colts allowed 486 points in sixteen games, an average of 30 points per match and the franchise worst since the 1981 Colts who allowed 533. At the time only the aforementioned Colts, the 1980 New Orleans Saints and the 1966 New York Giants (in a 14-game schedule) had ever allowed more points. This would be the last time the Colts would miss the playoffs until 2011 and the only time in the 2000s decade in which they didn't qualify.

This was the Colts' final season as a member of the AFC East, as they would move to the newly formed AFC South in the 2002 league re-alignment. It was also the final season Mark Rypien would play in the NFL.