2005–06 National Twenty20 Cup
| Dates | 24 February – 4 March 2006 |
|---|---|
| Administrator(s) | Pakistan Cricket Board |
| Cricket format | Twenty20 |
| Tournament format(s) | Round-robin and knockout |
| Host(s) | Karachi |
| Champions | Sialkot Stallions (1st title) |
| Participants | 13 |
| Matches | 39 |
The 2005–06 ABN-AMRO Twenty-20 Cup was the second season of the ABN-AMRO Twenty-20 Cup in Pakistan, sponsored by ABN AMRO. It was held in Karachi from 24 February to 4 March 2006. This edition featured an expanded format, with an increase from 19 to 39 matches and from 11 to 13 teams; the new teams being the Islamabad Leopards and the Abbottabad Rhinos. The Sialkot Stallions won the tournament by defeating the defending champions the Faisalabad Wolves in the final.