2005 Italian Open – Men's singles

Men's singles
2005 Italian Open
Champion Rafael Nadal
Runner-up Guillermo Coria
Score6–4, 3–6, 6–3, 4–6, 7–6(8–6)
Draw64 (4WC/8Q/1LL)
Seeds16

Rafael Nadal defeated Guillermo Coria in the final, 6–4, 3–6, 6–3, 4–6, 7–6(8–6) to win the men's singles tennis title at the 2005 Italian Open. Nadal was making his tournament debut, and it was the first of an eventual record ten Italian Open titles. The final is considered one of the best matches in tournament history.

Carlos Moyá was the defending champion, but lost in the first round to Potito Starace.