2005 US Open – Men's singles

Defending champion Roger Federer defeated Andre Agassi in the final, 6–3, 2–6, 7–6^(7–1), 6–1 to win the men's singles tennis title at the 2005 US Open. It was his second US Open title and sixth major title overall. This was Agassi's 15th and last appearance in a major final.

This was the first US Open in which future champions Novak Djokovic, Andy Murray and Stan Wawrinka competed in the main draw. Noteworthy in this tournament was a strong performance by American men, despite 2003 champion and former world No. 1 Andy Roddick losing in the first round. In addition to two-time US Open champion Agassi, wildcard James Blake reached the quarterfinals, upsetting world No. 2 Rafael Nadal in the third round before losing to Agassi. Robby Ginepri reached the semifinals and also lost to Agassi.

This marked the last major appearance of French Open champion Albert Costa.