2006 Italian Open – Women's singles

Women's singles
2006 Italian Open
Champion Martina Hingis
Runner-up Dinara Safina
Score6–2, 7–5
Draw56
Seeds16

Martina Hingis defeated Dinara Safina in the final, 6–2, 7–5 to win the women's singles tennis title at the 2006 Italian Open. It was her first title since coming out of retirement.

Amélie Mauresmo was the reigning champion, but withdrew due to illness.