2006 Tennis Masters Cup – Singles

Singles
2006 Tennis Masters Cup
Champion Roger Federer
Runner-up James Blake
Score6–0, 6–3, 6–4
Draw8

Roger Federer defeated James Blake in the final, 6–0, 6–3, 6–4 to win the singles tennis title at the 2006 Tennis Masters Cup. It was his third Tour Finals title.

David Nalbandian was the defending champion, but was defeated in the semifinals by Blake.