2006 US Open – Men's singles

Two-time defending champion Roger Federer defeated Andy Roddick in the final, 6–2, 4–6, 7–5, 6–1 to win the men's singles tennis title at the 2006 US Open. It was his third US Open title and ninth major title overall. Federer became the sixth man (after Jack Crawford, Don Budge, Frank Sedgman, Lew Hoad and Rod Laver) to reach all four major finals in one calendar year, and the first to do so since Laver in 1969. Also, he reached a record-equaling tenth consecutive major semifinal (streak starting at the 2004 Wimbledon Championships), matching Laver and Ivan Lendl.

This tournament marked the final professional appearance of eight-time major champion, Olympic gold medalist and former world No. 1 Andre Agassi; he was defeated by Benjamin Becker in the third round. Future champion Juan Martín del Potro made his first US Open appearance, losing to Alejandro Falla in the first round.