2006 US Open – Mixed doubles
| Mixed doubles | |
|---|---|
| 2006 US Open | |
| Champion | Martina Navratilova Bob Bryan |
| Runner-up | Květa Peschke Martin Damm |
| Score | 6–2, 6–3 |
Martina Navratilova and Bob Bryan defeated Květa Peschke and Martin Damm in the final, 6–2, 6–3 to win the mixed doubles tennis title at the 2006 US Open. It was Navratilova's 59th and final major title, 32 years after her first (at the 1974 French Open), and marked her final professional appearance.
Daniela Hantuchová and Mahesh Bhupathi were the reigning champions, but neither participated in the mixed doubles tournament this year.