2006 Wimbledon Championships – Women's singles

Amélie Mauresmo defeated Justine Henin-Hardenne in the final, 2–6, 6–3, 6–4 to win the ladies' singles tennis title at the 2006 Wimbledon Championships. It was her second and last major title, having won the Australian Open earlier in the year. Mauresmo was the first Frenchwoman to win Wimbledon since Suzanne Lenglen in 1925. Henin-Hardenne was attempting to complete the career Grand Slam.

Venus Williams was the defending champion, but lost in the third round to Jelena Janković.

With Serena Williams not competing due to a knee injury, this marked the only Wimbledon between 1999 and 2011 not to feature either of the Williams sisters in the final.

Li Na was the first Chinese player (male or female) to reach a major singles quarterfinal. This also marked the major debut of future world No. 2 Agnieszka Radwańska, who reached the fourth round as a wildcard before losing to Kim Clijsters.