2007 Sony Ericsson Open – Men's singles

Novak Djokovic defeated Guillermo Cañas in the final, 6–3, 6–2, 6–4 to win the men's singles tennis title at the 2007 Miami Open. It was his first Masters title, and the first of an eventual record 40 Masters titles. Djokovic did not lose a set during the tournament. Djokovic was the youngest men's singles champion in Miami Open history, until surpassed by Carlos Alcaraz in 2022.

Roger Federer was the two-time defending champion, but lost in the fourth round to Cañas.

This was the last Masters tournament to feature a best-of-five-sets final.