2008 French Open – Men's singles

Three-time defending champion Rafael Nadal defeated Roger Federer in a rematch of the two previous years' finals, 6–1, 6–3, 6–0 to win the men's singles tennis title at the 2008 French Open. It was his fourth French Open title and fourth major title overall. Nadal did not lose a set during the tournament (a feat he would repeat in 2010, 2017, and 2020). It marked the third consecutive year that Nadal defeated Federer in the French Open final, and the fourth consecutive year that Nadal defeated Federer at the French Open (extending back to the 2005 semifinals). On all four occasions that Nadal won the French Open, he defeated Federer while the latter was the world No. 1 player. This was Federer's worst loss at a major in his entire career. He was attempting to complete the career Grand Slam; he would achieve the feat the following year.

This tournament marked the final professional appearance of former world No. 1 and three-time champion Gustavo Kuerten; he lost to Paul-Henri Mathieu in the first round. It was also the last major for 2004 finalist and former world No. 3 Guillermo Coria; he lost in the first round to Tommy Robredo.