2008 Italian Open – Men's singles

Men's singles
2008 Italian Open
Champion Novak Djokovic
Runner-up Stanislas Wawrinka
Score4–6, 6–3, 6–3
Draw56 (4WC/7Q)
Seeds16

Novak Djokovic defeated Stanislas Wawrinka in the final, 4–6, 6–3, 6–3 to win the men's singles tennis title at the 2008 Italian Open.

Rafael Nadal was the three-time defending champion, but lost in the second round to Juan Carlos Ferrero. Notably, this marked the first of two instances that Nadal lost his opening match at a clay court tournament.

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