2010 Campeonato Ecuatoriano de Fútbol Serie A
| Season | 2010 | 
|---|---|
| Champions | LDU Quito (10th title) | 
| Relegated | Universidad Católica Macará  | 
| 2011 Copa Libertadores | LDU Quito Emelec Deportivo Quito  | 
| 2010 Copa Sudamericana | Emelec Barcelona Deportivo Quito  | 
| 2011 Copa Sudamericana | LDU Quito | 
| Matches played | 268 | 
| Goals scored | 644 (2.4 per match) | 
| Top goalscorer | Jaime Ayoví (23 goals) | 
| Biggest home win | LDU Quito 5–0 Emelec (February 28) El Nacional 5–0 Emelec (April 20) LDU Quito 5–0 Olmedo (June 20) Deportivo Quito 5–0 Universidad Católica (November 20)  | 
| Biggest away win | ESPOLI 0–4 Independiente José Terán (April 20) Independiente José Terán 0–4 LDU Quito (October 29)  | 
| Highest scoring | ESPOLI 5–3 El Nacional (February 27)  | 
← 2009  2011 →   | |
The 2010 Campeonato Ecuatoriano de Fútbol de la Serie A (known as the 2010 Copa Credife Serie A for sponsorship reasons) was the 52nd season of the Serie A, Ecuador's premier football league. It ran from February 7 to December 12.
Emelec and LDU Quito each won the First and Second Stage, respectively, and played each other in the championship finals. LDU Quito won the first leg at home by a score of 2–0. Emelec could not overturn the deficit with a 1–0 win at home in the second leg. LDU Quito won their tenth national title, tying them for third overall with Emelec.