2010 Sony Ericsson Open – Women's singles
| Women's singles | |
|---|---|
| 2010 Sony Ericsson Open | |
| Champion | Kim Clijsters |
| Runner-up | Venus Williams |
| Score | 6–2, 6–1 |
| Draw | 96 |
| Seeds | 32 |
Kim Clijsters defeated Venus Williams in the final, 6–2, 6–1 to win the women's singles tennis title at the 2010 Miami Open. It was her second Miami Open title.
Victoria Azarenka was the defending champion, but lost to Clijsters in the fourth round.