2010 Tirreno–Adriatico| 2010 UCI World Ranking, race 3 of 26 |
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| Dates | 10–16 March 2010 |
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| Stages | 7 |
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| Distance | 1,229 km (763.7 mi) |
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| Winning time | 30h 52' 32" |
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The 2010 Tirreno–Adriatico was the 45th running of the Tirreno–Adriatico stage race. It started on 10 March and finished on 16 March. The race started in Livorno and ended San Benedetto del Tronto. The race was won by Stefano Garzelli after gaining 2 seconds in intermediate sprints in the last stage which tied him for first with Michele Scarponi; Garzelli held the tiebreaker, combined stage finishes.