2010 US Open – Wheelchair women's singles
| Wheelchair women's singles | |
|---|---|
| 2010 US Open | |
| Champion | Esther Vergeer |
| Runner-up | Daniela Di Toro |
| Score | 6–0, 6–0 |
Four-time defending champion Esther Vergeer defeated Daniela Di Toro in the final, 6–0, 6–0 to win the women's singles wheelchair tennis title at the 2010 US Open.