2010 Wimbledon Championships – Women's singles

Defending champion Serena Williams defeated Vera Zvonareva in the final, 6–3, 6–2 to win the ladies' singles tennis title at the 2010 Wimbledon Championships. It was her fourth Wimbledon singles title and 13th major singles title overall. Williams did not lose a set during the tournament. Zvonareva was contesting her first major singles final, and was the second lowest-ranked woman to contest the final.

The reigning French Open champion Francesca Schiavone and runner-up Samantha Stosur both lost in the first round, marking the first time that the two French Open finalists lost in the opening round of Wimbledon.

Petra Kvitová (ranked 62nd) and Tsvetana Pironkova (ranked 82nd) reached the semifinals, marking the first time since 1999 that two unseeded players reached the semifinals. Pironkova became the first Bulgarian woman to reach a major semifinal.