2011 US Open – Men's singles

Novak Djokovic defeated defending champion Rafael Nadal in a rematch of the previous year's final, 6–2, 6–4, 6–7^(3–7), 6–1 to win the men's singles tennis title at the 2011 US Open. It was his first US Open title and fourth major title overall. Djokovic saved two match points en route to the title, against Roger Federer in the semifinals. This was the second consecutive US Open where Djokovic saved two match points against Federer to reach the final, and the fifth consecutive US Open where the pair played each other. Federer's defeat meant that he did not win a major in a calendar year for the first time since 2002.

Andy Roddick and John Isner, who both lost in the quarterfinals, remained the last American men to reach a major quarterfinal until Sam Querrey at the 2016 Wimbledon Championships, a span of 22 events.

This marked the last US Open appearance of 2003 finalist and former world No. 1 Juan Carlos Ferrero.