2012 Australian Open – Women's singles

Victoria Azarenka defeated Maria Sharapova in the final, 6–3, 6–0 to win the women's singles tennis title at the 2012 Australian Open. It was her first major title. Azarenka was the first Belarusian to win a singles major, and became the world No. 1 in doing so. Caroline Wozniacki, Petra Kvitová and Sharapova were also in contention for the top ranking.

Kim Clijsters was the defending champion, but was defeated in the semifinals by Azarenka.

For the first time in the tournament's history, all eight quarterfinalists were European. This was also the first major main draw appearance for future three-time major champion and world No. 1 Ashleigh Barty, who was defeated in the first round by Anna Tatishvili.

This tournament marked the first Australian Open appearance of future champion Madison Keys; she lost to Zheng Jie in the first round.