2012 EPZ Omloop van Borsele

The 2012 EPZ Omloop van Borsele was the 11th running of the Omloop van Borsele, a women's cycling event in 's-Heerenhoek, the Netherlands. New this year was the introduction of an individual time trial, held on 20 April over a distance of 18 kilometres (11.2 miles). The road race was held on 21 April 2012 over a distance of 121.5 kilometres (75.5 miles). It was rated by the UCI as 1.2 category race.

After winning the time trial of Borsele, Team Specialized–lululemon rider Ellen van Dijk won also the road race of the EPZ Omloop van Borsele. She won the sprint of a group of seven riders ahead of Gracie Elvin from Australia (Australian national team) and Sarah Düster from Germany (Rabobank Women Cycling Team).