2012 US Open – Men's singles

Andy Murray defeated defending champion Novak Djokovic in the final, 7–6^(12–10), 7–5, 2–6, 3–6, 6–2 to win the men's singles tennis title at the 2012 US Open. It was his first major title, following four runner-up finishes. Murray was the first British man to win a singles major since Fred Perry in 1936. The final lasted 4 hours and 54 minutes, an Open Era record-equaling US Open final duration.

This tournament marked the last professional appearance of 2003 champion and former world No. 1 Andy Roddick; he lost to Juan Martín del Potro in the fourth round.

This tournament marked the first time since the 2004 French Open that neither Roger Federer nor Rafael Nadal (who withdrew from the tournament due to a knee injury) reached the semifinals of a major.

Murray's victory made 2012 the first season since 2003 to feature four different champions across the four majors.