2013 Western & Southern Open – Women's singles

Women's singles
2013 Western & Southern Open
Champion Victoria Azarenka
Runner-up Serena Williams
Score2–6, 6–2, 7–6(8–6)
Draw56
Seeds16

Victoria Azarenka defeated Serena Williams in the final, 2–6, 6–2, 7–6(8–6) to win the women's singles tennis title at the 2013 Cincinnati Masters. It was Azarenka's second win against Williams during the year, and Williams' fourth and last loss of the year.

Li Na was the defending champion, but lost to Williams in the semifinals.

This marked the final professional appearance of reigning Wimbledon champion Marion Bartoli; she lost to Simona Halep in the second round.