2016 Mutua Madrid Open – Women's singles
| Women's singles | |
|---|---|
| 2016 Mutua Madrid Open | |
| Champion | Simona Halep |
| Runner-up | Dominika Cibulková |
| Score | 6–2, 6–4 |
Simona Halep defeated Dominika Cibulková in the final, 6–2, 6–4 to win the women's singles tennis title at the 2016 Madrid Open.
Petra Kvitová was the defending champion, but lost in the third round to Daria Gavrilova.