2018 US Open – Mixed doubles
| Mixed doubles | |
|---|---|
| 2018 US Open | |
| Champions | Bethanie Mattek-Sands Jamie Murray | 
| Runners-up | Alicja Rosolska Nikola Mektić | 
| Score | 2–6, 6–3, [11–9] | 
Martina Hingis and Jamie Murray were the defending champions, but Hingis retired from professional tennis at the end of 2017. Murray successfully defended his title alongside Bethanie Mattek-Sands, defeating Alicja Rosolska and Nikola Mektić, 2–6, 6–3, [11–9] to win the mixed doubles tennis title at the 2018 US Open.