2019 Miami Open – Men's singles
| Men's singles | |
|---|---|
| 2019 Miami Open | |
| Champion | Roger Federer |
| Runner-up | John Isner |
| Score | 6–1, 6–4 |
| Draw | 96 (12 Q / 5 WC ) |
| Seeds | 32 |
Roger Federer defeated defending champion John Isner in the final, 6–1, 6–4 to win the men's singles tennis title at the 2019 Miami Open. It was his fourth Miami Open title, his 28th and final Masters singles title, and his 101st career singles title overall. Federer became the oldest Masters 1000 champion since the series was established in 1990.
Félix Auger-Aliassime became the youngest men's singles semifinalist in the tournament's 35-year history, and the first teenage semifinalist since Andy Murray and Novak Djokovic in 2007.