2020 Italian Open – Men's singles

Men's singles
2020 Italian Open
Champion Novak Djokovic
Runner-up Diego Schwartzman
Score7–5, 6–3
Draw56 (8 Q / 4 WC )
Seeds16

Novak Djokovic defeated Diego Schwartzman in the final, 7–5, 6–3 to win the men's singles tennis title at the 2020 Italian Open. It was his fifth Italian Open title and record 36th Masters 1000 title overall. Djokovic entered his 287th week as world No. 1 (surpassing Pete Sampras for the second-most of all time) following the tournament.

Rafael Nadal was the two-time defending champion, but lost to Schwartzman in the quarterfinals.

Casper Ruud became the first Norwegian to reach a Masters semifinal, surpassing his father Christian Ruud, who reached the quarterfinals of Monte Carlo in 1997.

By defeating Stan Wawrinka in the first round, Lorenzo Musetti became the first player born in 2002 to win an ATP match.