2021–22 2. Frauen-Bundesliga
| Season | 2021–22 |
|---|---|
| Dates | 15 August 2021 – 5 June 2022 |
| Champions | SV Meppen |
| Promoted | SV Meppen MSV Duisburg |
| Relegated | SV Elversberg SV Henstedt-Ulzburg Borussia Bocholt |
| Matches played | 182 |
| Goals scored | 636 (3.49 per match) |
| Top goalscorer | Nastassja Lein Ramona Maier (25 goals) |
| Biggest home win | Gütersloh 6–0 Wolfsburg II |
| Biggest away win | Bocholt 1–9 Leipzig |
| Highest scoring | Bocholt 1–9 Leipzig |
| Longest winning run | 5 games Meppen |
| Longest unbeaten run | 5 games Meppen |
| Longest winless run | 7 games Wolfsburg II |
| Longest losing run | 4 games Wolfsburg II |
| Attendance | 26,407 (145 per match) |
← 2020–21 2022–23 → | |
The 2021–22 2. Frauen-Bundesliga was the 18th season of Germany's second-tier women's football league, and the fourth as a single-division league. The season began on 15 August 2021 and concluded on 5 June 2022. The champions and runners-up will be promoted to the Frauen-Bundesliga, while the bottom three teams will be relegated to the Frauen-Regionalliga.
The fixtures were announced on 23 July 2021.