2021–22 2. Liga (Slovakia)
| Season | 2021–22 | 
|---|---|
| Champions | Podbrezová | 
| Promoted | Podbrezová  Dukla Banská Bystrica Skalica  | 
| Relegated | Námestovo  Partizán Bardejov Slovan Bratislava U21 Rohožník  | 
| Matches played | 240 | 
| Goals scored | 676 (2.82 per match) | 
| Top goalscorer | Marek Kuzma (22) | 
← 2020–21  2022–23 →   | |
The 2021–22 2. Liga was the 29th season of the 2. Liga in Slovakia, since its establishment in 1993.