The 2021–22 Brisbane Heat Women's season was the seventh in the team's history. Coached by Ashley Noffke and captained by Jess Jonassen, the Heat were scheduled to play four of 14 regular season WBBL|07 games at Great Barrier Reef Arena in Mackay—the only fixtures in their home state of Queensland for the tournament due to construction work taking place at regular primary ground Allan Border Field. They finished in third place on the ladder, resulting in their fourth consecutive finals series appearance. However, for the second year in a row, the Heat were eliminated by a lower-ranked opponent in their first match of the knockout stage—this time suffering a "crushing" eight-wicket defeat at the hands of the Adelaide Strikers.