2021–22 Campionato Sammarinese di Calcio
| Season | 2021–22 |
|---|---|
| Dates | 18 September 2021–26 May 2022 |
| Champions | La Fiorita |
| Champions League | La Fiorita |
| Conference League | Tre Penne Tre Fiori (via Coppa Titano) |
| Matches played | 232 |
| Goals scored | 567 (2.44 per match) |
← 2020–21 2022–23 → | |
The 2021–22 Campionato Sammarinese di Calcio was the 37th season of league competition in San Marino, in which the country's top 15 amateur football teams competed. The season began on 18 September 2021 and ended on 26 May 2022. The winners of the league, La Fiorita qualified for a place in the 2022–23 UEFA Champions League. Runners-up, Tre Penne qualified for a place in the 2022–23 UEFA Europa Conference League.
Folgore were the defending champions after winning the title in the previous season, but failed to defend their title as Fiorentino knocked them out in the play-offs. La Fiorita won their sixth title by defeating Tre Penne in the final, 2–0.