2021–22 Fifty50 Challenge
| Dates | 26 February – 12 March 2022 |
|---|---|
| Administrator(s) | Zimbabwe Cricket |
| Cricket format | 50 over |
| Tournament format(s) | Double round-robin and final |
| Champions | Eagles (1st title) |
| Participants | 4 |
| Matches | 13 |
| Most runs | Josephine Nkomo (268) |
| Most wickets | Michelle Mavunga (15) |
The 2021–22 Fifty50 Challenge was the second edition of the Fifty50 Challenge, a 50-over women's cricket competition played in Zimbabwe. The tournament took place in February and March 2022, with four teams competing in a double round-robin group stage.
Eagles won the competition, beating Rhinos in the final. The tournament was followed by the Women's T20 Cup.